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Doctor's Best

Doctor's Best SAMe 400mg Double Strength

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30 tablets

RRP: $63.80

You save 21% ($13.70)


RRP: $63.80

You save 21% ($13.70)

Doctor's Best SAMe 400mg Double Strength (S-Adenosylmethionine) is derived from the amino acid methionine and it is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function
SAMe may support cartilage protection and synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to support mobility and movement, and promote joint comfort.

SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also aid upregulation of the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function
SAMe supports liver synthesis of glutathione, an essential antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.


Adults: Take 1 tablet daily away from food, or as recommended by a nutritionally-informed physician. Do not chew or crush tablet.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe.

Do not use if pregnant or nursing.

May cause gastrointestinal discomfort in a small percentage of people.
Always read the label. Use only as directed.

Keep all medications and supplements out of reach of children.

Store product in a cool, dry place to ensure maximum quality.



Each Tablet Provides:
S-Adenosyl Methionine (from 800 mg of SAMe tosylate disulfate) 400 mg

Other Ingredients: Cellulose, methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch and iron oxide. The SAMe found in Doctor's Best SAMe 400 mg (Double Strength) is free from yeast, dairy, gluten, soy, wheat and artificial flavoring. Contains nothing other than listed ingredients

Doctor's Best

Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, most made with branded ingredients, that are thoroughly researched and tested to the highest quality standards.

Your satisfaction is of paramount importance to us! If we can help in any way please contact us using the details below.

Email: [email protected]

Australia Free Phone: 1800 040 156

Other Countries Phone: +64 3 265 9758

Live Chat: Between the hours of 7am – 3pm AEST

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Product Highlights

  • Promotes enhanced mood 
  • For joint function 
  • For liver function


  • TRUSTED NZ SUPPLIER To Australia for over 20 years
  • FREE DELIVERY Free Tracked Airmail Delivery within Australia When You Spend Over $79
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    30 Days Hassle Free Return Service

    Your satisfaction is extremely important to us. Any problems will be addressed in a friendly and efficient manner, with your total satisfaction as our over-riding concern.

    Our Return Policy

    If you have changed your mind about a product and it is in re-saleable condition (unopened, with undamaged packaging) you can return it within 30 days of receipt for a full refund.

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