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Life Extension

Life Extension Optimized Resveratrol 250mg

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60 vegecaps

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Life Extension Optimized Resveratrol 250mg is a full spectrum, trans-resveratrol formula. Life Extension has identified certain compounds that mimic calorie restriction’s ability to trigger youthful gene expression, the process by which genes transmit signals that slow certain aspects of aging. These compounds include trans-resveratrol (which researchers contend is the most active constituent), quercetin, plus certain compounds found in berries, including trans-pterostilbene and now fisetin.

Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by Vitis vinifera as a response to attack by molds. Because of the widespread use of pesticides in modern wine making, including the practice of copper sulfation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement.

Research funded by the Life Extension Foundation showed that a combination of low-dose (20mg) resveratrol plus grapeseed extract mimicked many of the favorable gene expression changes seen in calorie-restricted animals. Other studies, however, indicate that higher doses may be needed to obtain all of resveratrol’s positive benefits including helping promote healthy insulin sensitivity, enhanced mitochondrial function, reduced expression of inflammatory factors, and protection against the toxic effects of a high-fat diet.

Life Extension has evaluated published studies on resveratrol to establish the doses humans might need to take to duplicate the remarkable laboratory findings. The results of Life Extension’s analysis yield a wide range of potentially effective doses: from 20 to 250mg a day and higher. The resveratrol potency you choose may be based on your current state of health and/or your desire to reach the upper limits of a healthy human life span.

Pterostilbene, a stilbene compound from the same family as resveratrol, has been shown to work synergistically with resveratrol, to unlock one’s longevity genes … thus conferring even greater anti-aging benefits.

Fisetin, found in strawberries, may have the power to “switch on” cell signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function. Fisetin also helps support aging neurons in the presence of oxidative stress. And, most importantly, it works in synergy with resveratrol. Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown, thus extending its beneficial effects! So naturally we added it, along with these other four calorie restriction mimics, to this most advanced resveratrol formulation.


Take one capsule daily with or without food, or as recommended by a healthcare practitioner.


If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

Each Capsule Provides:

Trans-resveratrol [from Polygonum cuspidatum extract (root) and whole red grape (Vitis vinifera) extract] [also supplying glycosides (polydatin)] 250mg
Red Grape (Full Spectrum French Red Wine Polyphenol Profile), Wild Blueberry (Vaccinium angustifolium), and Polygonum cuspidatum extract blend 85mg
[supplying polyphenols, anthocyanins, OPCs, free resveratrol, resveratrol conjugates (epsilon-viniferin, trans and cis-polydatin), and resveratrol analogs (pterostilbene)]
Quercetin (as quercetin dihydrate) 60mg
Trans-Pterostilbene (as pure Pterospan and SMART pterostilbene) 0.5mg
Fisetin [from (Rhus succedanea L.) extract (stem)] 10mg

Also contains: Vegetable cellulose (capsule), silica, vegetable stearate, maltodextrin.

Life Extension

The Life Extension Foundation is the world’s largest membership organization dedicated to investigating every method of extending the healthy human life span and funding anti-aging research. Based on current scientific research, Life Extension is continually formulating and upgrading its science-based multivitamin, vitamin, and nutritional supplement formulas to include the latest novel ingredients that are years ahead of mainstream offerings.

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